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Although not implemented in practice, pre-clinical studies with xenograft models have given positive responses, with models showing reduced growth in tumours, singly or in combination with therapeutic interventions [148, 150,151,152,153,154], with some exceptions where no benefit was observed [155, 156]

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Barile and colleagues highlighted the multifaceted roles of flavins and flavoproteins, noting that RFK and FADS are poorly investigated in cancer 9